Concise Review: Bone Marrow‐Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration

Our understanding of the role of bone marrow (BM)‐derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells. Recent studies, however, suggest that the BM contributes a significant proportion of noninflammatory cells to the skin, which ar...

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Bibliographic Details
Published in:Stem cells (Dayton, Ohio) Ohio), 2010-05, Vol.28 (5), p.905-915
Main Authors: Wu, Yaojiong, Zhao, Robert C. H., Tredget, Edward E.
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - cytology
Bone Marrow Cells - physiology
Bone Marrow Transplantation - methods
Bone Marrow Transplantation - trends
Cutaneous regeneration
Dermatologic Surgical Procedures
Endothelial progenitor cells
Fibrocytes
Humans
Mesenchymal stem cells
Regeneration - physiology
Skin - cytology
Skin - injuries
Stem Cell Technology: Epigenetics, Genomics, Proteomics, and Metabonomics
Stem Cells - cytology
Stem Cells - physiology
Wound healing
Wound Healing - physiology
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Summary:Our understanding of the role of bone marrow (BM)‐derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells. Recent studies, however, suggest that the BM contributes a significant proportion of noninflammatory cells to the skin, which are present primarily in the dermis in fibroblast‐like morphology and in the epidermis in a keratinocyte phenotype; and the number of these BM‐derived cells increases markedly after wounding. More recently, several studies indicate that mesenchymal stem cells derived from the BM could significantly impact wound healing in diabetic and nondiabetic animals, through cell differentiation and the release of paracrine factors, implying a profound therapeutic potential. This review discusses the most recent understanding of the contribution of BM‐derived noninflammatory cells to cutaneous homeostasis and wound healing. STEM CELLS 2010;28:905–915
ISSN:1066-5099
1549-4918
DOI:10.1002/stem.420