A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus

22 of 61 systemic lupus erythematosus (SLE) patients produced antibodies to the p24 gag protein of HIV-1 demonstrated by Western blotting. 20 of these 22 patients (91%) also express the 4B4 idiotype (Id 4B4) previously identified on a human anti-Sm monoclonal antibody called 4B4. This represents an...

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Bibliographic Details
Published in:The Journal of clinical investigation 1990-06, Vol.85 (6), p.1866-1871
Main Authors: TALAL, N, GARRY, R. F, SCHUR, P. H, ALEXANDER, S, DAUPHINEE, M. J, LIVAS, I. H, BALLESTER, A, TAKEI, M, DANG, H
Format: Article
Language:English
Subjects:
AIDS/HIV
Autoantigens - immunology
Biological and medical sciences
Blotting, Western
Cross Reactions
Gene Products, gag - immunology
HIV Antibodies - immunology
HIV Antigens - immunology
HIV Core Protein p24
HIV-1 - immunology
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin Idiotypes - immunology
Immunopathology
Lupus Erythematosus, Systemic - immunology
Medical sciences
Retroviridae Proteins - immunology
Ribonucleoproteins, Small Nuclear
snRNP Core Proteins
Viral Core Proteins - immunology
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Summary:22 of 61 systemic lupus erythematosus (SLE) patients produced antibodies to the p24 gag protein of HIV-1 demonstrated by Western blotting. 20 of these 22 patients (91%) also express the 4B4 idiotype (Id 4B4) previously identified on a human anti-Sm monoclonal antibody called 4B4. This represents an enrichment for this Id (seen in only 52% of SLE patients generally). Eight of these 22 SLE patients also have anti-Sm antibody activity. Sm partially inhibits the antibody binding of p24 gag suggesting immunologic cross-reactivity between the retroviral antigen p24 gag and the autoantigen Sm. Anti-Id 4B4 also inhibits p24 gag antibody binding by as much as 40%. Finally the monoclonal antibody 4B4 showed cross-reactivity to Sm and p24 gag. The following points emerge from our studies: (a) SLE patients make antibodies to p24 gag of HIV-1, (b) there is a relationship between immunity to p24 gag and a conserved idiotype, and (c) anti-Sm antibodies can cross-react with p24 gag.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI114647