The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore

We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoa...

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Bibliographic Details
Published in:The Journal of clinical investigation 1990-07, Vol.86 (1), p.279-285
Main Authors: COURVALIN, J.-C, LASSOUED, K, BARTNIK, E, BLOBEL, G, WOZNIAK, R. W
Format: Article
Language:English
Subjects:
Autoantigens - immunology
Biological and medical sciences
Blotting, Western
Fluorescent Antibody Technique
Humans
Immunopathology
Liver Cirrhosis, Biliary - immunology
Medical sciences
Membrane Glycoproteins - immunology
Molecular Weight
Nuclear Envelope - immunology
Nuclear Proteins - immunology
Precipitin Tests
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Summary:We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.
ISSN:0021-9738
1558-8238
DOI:10.1172/jci114696