It takes two to tango: mast cell and Schwann cell interactions in neurofibromas

Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1)...

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Bibliographic Details
Published in:The Journal of clinical investigation 2003-12, Vol.112 (12), p.1791-1793
Main Author: Viskochil, David H
Format: Article
Language:English
Subjects:
Alleles
Animals
Biomedical research
Disease Progression
Fibroblasts - metabolism
Humans
Mast Cells - metabolism
Mice
Mice, Transgenic
Models, Biological
Mutation
Neoplasms - metabolism
Neurofibroma - metabolism
Neurofibromin 1 - metabolism
Schwann Cells - metabolism
Signal Transduction
Stem Cell Factor - metabolism
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Summary:Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could influence the multicellular microenvironment of neurofibromas to inhibit the development and/or progression of these tumors in human NF1.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI200320503