Absorption of L-methionine from the human small intestine

Absorption of L-methionine was measured in all parts of the human small intestine using transintestinal intubation and perfusion. In four normal subjects, adsorption was higher in the proximal than in the distal intestine. In two patients with nontropical sprue in relapse, there was a proximal zone...

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Bibliographic Details
Published in:The Journal of clinical investigation 1968-02, Vol.47 (2), p.417-425
Main Authors: Schedl, H P, Pierce, C E, Rider, A, Clifton, J A
Format: Article
Language:English
Subjects:
Adult
Arteriosclerosis - metabolism
Celiac Disease - metabolism
Female
Humans
Intestinal Absorption
Intestine, Small - metabolism
Male
Methionine - metabolism
Middle Aged
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Summary:Absorption of L-methionine was measured in all parts of the human small intestine using transintestinal intubation and perfusion. In four normal subjects, adsorption was higher in the proximal than in the distal intestine. In two patients with nontropical sprue in relapse, there was a proximal zone of low absorption with higher absorption distally. In all parts of the small intestine, absorption showed rate-limiting kinetics as methionine concentration was increased. In normal subjects, the proximal K(m) (Michaelis constant) was more than 3 times higher than the distal, which suggests a difference in transport mechanisms between the two segments.
ISSN:0021-9738
DOI:10.1172/JCI105738