Growth hormone secretion during sleep

Plasma growth hormone (GH), insulin, cortisol, and glucose were measured during sleep on 38 nights in eight young adults. Blood was drawn from an indwelling catheter at 30-min intervals; EEG and electrooculogram were recorded throughout the night. In seven subjects, a plasma GH peak (13-72 mmug/ml)...

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Bibliographic Details
Published in:The Journal of clinical investigation 1968-09, Vol.47 (9), p.2079-2090
Main Authors: Takahashi, Y, Kipnis, D M, Daughaday, W H
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
Chlordiazepoxide - pharmacology
Chlorpromazine - pharmacology
Electroencephalography
Eye Movements
Female
Growth Hormone - blood
Growth Hormone - secretion
Humans
Hydrocortisone - blood
Imipramine - pharmacology
Insulin - blood
Isocarboxazid - pharmacology
Male
Phenobarbital - pharmacology
Phenytoin - pharmacology
Secretory Rate - drug effects
Sleep - physiology
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Summary:Plasma growth hormone (GH), insulin, cortisol, and glucose were measured during sleep on 38 nights in eight young adults. Blood was drawn from an indwelling catheter at 30-min intervals; EEG and electrooculogram were recorded throughout the night. In seven subjects, a plasma GH peak (13-72 mmug/ml) lasting 1.5-3.5 hr appeared with the onset of deep sleep. Smaller GH peaks (6-14 mmug/ml) occasionally appeared during subsequent deep sleep phases. Peak GH secretion was delayed if the onset of sleep was delayed. Subjects who were awakened for 2-3 hr and allowed to return to sleep exhibited another peak of GH secretion (14-46 mmug/ml). Peak GH secretion was not correlated with changes in plasma glucose, insulin, and cortisol. The effects of 6-CNS-active drugs on sleep-related GH secretion were investigated. Imipramine (50 mg) completely abolished GH peaks in two of four subjects, whereas chlorpromazine (30 mg), phenobarbital (97 mg), diphenylhydantoin (90 mg), chlordiazepoxide (20 mg), and isocarboxazid (30 mg) did not inhibit GH peaks. Altered hypothalamic activity associated with initiation of sleep results in a major peak of growth hormone secretion unrelated to hypoglycemia or changes in cortisol and insulin secretion.
ISSN:0021-9738
DOI:10.1172/JCI105893