Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors

Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a series of lineage restriction steps that results in the progressive loss of differentiation potential to other cell lineages. This review focuses on the recent advances in understanding one of the earliest di...

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Bibliographic Details
Published in:Immunological reviews 2010-11, Vol.238 (1), p.37-46
Main Author: Kondo, Motonari
Format: Article
Language:English
Subjects:
Animals
Blood cells
Bone marrow
Bone Marrow - growth & development
Bone Marrow - immunology
bone marrow microenvironment
Cell lineage
Cell Lineage - immunology
cytokine
Cytokines - immunology
Differentiation
G-protein coupled receptors
hematopoiesis
Hematopoiesis - immunology
Hemopoiesis
Humans
Lymphoid Progenitor Cells - immunology
lymphopoiesis
Microenvironments
Multipotent Stem Cells - immunology
Myeloid cells
Myeloid Progenitor Cells - immunology
Stem cells
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Summary:Hematopoietic stem cells (HSCs) continuously replenish all classes of blood cells through a series of lineage restriction steps that results in the progressive loss of differentiation potential to other cell lineages. This review focuses on the recent advances in understanding one of the earliest differentiation steps in HSC maturation, which involves the diversification of the lymphoid and myeloid cell lineages, the two major branches of hematopoietic cells. We discuss progress in the identification and characterization of progenitor populations downstream of HSCs, which has been a key to understanding the sequential biological events that take place along the course of differentiation into a certain hematopoietic cell type. We also discuss the importance of bone marrow microenvironment in lymphoid and myeloid lineage choice.
ISSN:0105-2896
1600-065X
DOI:10.1111/j.1600-065X.2010.00963.x