Development of Lapachol Topical Formulation: Anti-inflammatory Study of a Selected Formulation

This study aimed at developing a topical formulation of lapachol, a compound isolated from various Bignoniaceae species and at evaluating its topical anti-inflammatory activity. The influence of the pharmaceutical form and different types of emulsifiers was evaluated by in-vitro release studies. The...

Full description

Saved in:
Bibliographic Details
Published in:AAPS PharmSciTech 2008, Vol.9 (1), p.163-168
Main Authors: Lira, Ana Amélia M., Sester, Elizângela A., Carvalho, André Luis M., Strattmann, Ruth R., Albuquerque, Miracy M., Wanderley, Almir G., Santana, Davi P.
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - chemistry
Bignoniaceae
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Diffusion
Drug Carriers - chemistry
Drug Compounding - methods
Drug Evaluation, Preclinical
Inflammation - diagnosis
Inflammation - drug therapy
Materials Testing
Naphthoquinones - administration & dosage
Naphthoquinones - chemistry
Pharmacology/Toxicology
Pharmacy
Rats
Rats, Wistar
Research Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed at developing a topical formulation of lapachol, a compound isolated from various Bignoniaceae species and at evaluating its topical anti-inflammatory activity. The influence of the pharmaceutical form and different types of emulsifiers was evaluated by in-vitro release studies. The formulations showing the highest release rate were selected and assessed trough skin permeation and retention experiments. It was observed that the gel formulation provided significantly higher permeation and retained amount (3.9-fold) of lapachol as compared to the gel-cream formulation. Antinociceptive and antiedematogenic activities of the most promising formulation were also evaluated. Lapachol gel reduced the increase in hind-paw volume induced by carrageenan injection and reduced nociception produced by acetic acid (0.8% in water, i.p.) when used topically. These results suggest that topical delivery of lapachol from gel formulations may be an effective medication for both dermal and subdermal injuries.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-007-9002-z