Ultrasound Transmission Technique as a Potential Tool for Physical Evaluation of Monolithic Matrix Tablets

• Published in: AAPS PharmSciTech 2008-03, Vol.9 (1), p.267-273
• Main Authors: Hakulinen, M. A., Pajander, J., Leskinen, J., Ketolainen, J., van Veen, B., Niinimäki, K., Pirskanen, K., Poso, A., Lappalainen, R.
• Format: Article
• Language: English
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Drug Evaluation, Preclinical - methods; Feasibility Studies; Materials Testing - methods; Particle Size; Pharmacology/Toxicology; Pharmacy; Porosity; Powders - chemistry; Research Article; Starch - analogs & derivatives; Starch - chemistry; Tablets - chemistry; Ultrasonics
• ISSN: 1530-9932; 1530-9932
• DOI: 10.1208/s12249-007-9010-z

The aim of this study was to investigate the effects of tablet porosity and particle size fraction of compacted Starch acetate powders, with and without model drug caffeine, on acoustic properties of tablets. The ultrasound velocity was determined from the transmission measurements. Tablets of starch acetate (SA DS 2.7) powder with two particle size fractions of 0–53 and 0–710 μm were compressed with a compaction simulator. Porosities of tablets varied in the range from 12% to 43% for both particle size fractions. Strong associations were found between the ultrasound velocity and physical properties of the tablets such as porosity and particle size fraction. Interestingly, ultrasound velocity was practically insensitive to inclusion of the model drug caffeine with the concentrations used. Based on this study ultrasound transmission method is a potential non-destructive tool for studying structural changes of tablets and other solid dosage forms.