p53 post-translational modification: deregulated in tumorigenesis

The p53 tumor suppressor protein has well-established roles in monitoring various types of stress signals by activating specific transcriptional targets that control cell cycle arrest and apoptosis, although some activities are also mediated in a transcription-independent manner. Here, we review the...

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Bibliographic Details
Published in:Trends in molecular medicine 2010-11, Vol.16 (11), p.528-536
Main Authors: Dai, Chao, Gu, Wei
Format: Article
Language:English
Subjects:
Acetylation
Animals
Apoptosis
Gene Expression Regulation, Neoplastic
Humans
Methylation
Neoplasms - genetics
Neoplasms - metabolism
Pathology
Phosphorylation
Protein Processing, Post-Translational
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
Ubiquitination
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Summary:The p53 tumor suppressor protein has well-established roles in monitoring various types of stress signals by activating specific transcriptional targets that control cell cycle arrest and apoptosis, although some activities are also mediated in a transcription-independent manner. Here, we review the recent advances in our understanding of the wide spectrum of post-translational modifications that act as epigenetic-like codes for modulating specific functions of p53 in vivo and how deregulation of these modifications might contribute to tumorigenesis. We also discuss future research priorities to further understand p53 post-translational modifications and the interpretation of genetic data in appreciation of the increasing evidence that p53 regulates cellular metabolism, autophagy and many unconventional tumor suppressor activities.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2010.09.002