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RNA processing and export

Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by mo...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2010-12, Vol.2 (12), p.a000752-a000752
Main Authors: Hocine, Sami, Singer, Robert H, Grünwald, David
Format: Article
Language:English
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Summary:Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a000752