Expression of urocortin peptides in canine myocardium and plasma

Urocortin (Ucn) peptides are the endogenous ligands for the corticotropin-releasing factor type 2 receptor (CRFR2). They have potentially important roles in cardiovascular physiology in health and disease, and show promise as therapeutics for congestive heart failure. Analysis of canine heart tissue...

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Bibliographic Details
Published in:The veterinary journal (1997) 2011-06, Vol.188 (3), p.318-324
Main Authors: Veloso, Gemma Fraga, Ohad, Dan G., Francis, Andrew J., Vaughan, Joan M., Brownstein, David G., Culshaw, Geoffrey J., Vale, Wylie W., French, Anne T., Jamieson, Pauline M.
Format: Article
Language:English
Subjects:
Animals
biomarkers
Biomarkers - blood
Biomarkers - metabolism
Cardiac disease
cardiomyocytes
Cardiovascular Diseases - blood
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - veterinary
Case-Control Studies
Corticotropin-releasing factor receptor
corticotropin-releasing hormone
Dog
Dog Diseases - blood
Dog Diseases - metabolism
Dogs
Female
gene expression
Heart
heart failure
immunohistochemistry
Male
messenger RNA
myocardium
Myocardium - metabolism
Myocytes, Cardiac - metabolism
patients
physiology
radioimmunoassays
Receptors, Corticotropin-Releasing Hormone - metabolism
RNA, Messenger - metabolism
therapeutics
Urocortin
Urocortins - blood
Urocortins - metabolism
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Summary:Urocortin (Ucn) peptides are the endogenous ligands for the corticotropin-releasing factor type 2 receptor (CRFR2). They have potentially important roles in cardiovascular physiology in health and disease, and show promise as therapeutics for congestive heart failure. Analysis of canine heart tissue showed mRNA expression of Ucn 1, Ucn 3 and CRFR2 in all heart chambers. Immunohistochemistry also demonstrated Ucns 1 and 3 expression in cardiomyocytes. To assess the potential usefulness of circulating Ucns as markers of heart disease, plasma samples from 45 dogs with cardiac disease and 15 controls were analysed by radioimmunoassay. Both Ucns 1 and 3 were measurable but the presence of cardiac disease did not alter their concentrations. Therefore, whilst Ucns are expressed in canine myocardium (where they may play a role in the endogenous neurohumoral response to cardiac disease or failure) they do not appear to be sensitive biomarkers of cardiac disease in our canine patient population.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2010.05.019