Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release

Micelles are colloidal particles with a size around 5-100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use...

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Bibliographic Details
Published in:Pharmaceutical research 2010-12, Vol.27 (12), p.2569-2589
Main Authors: Oerlemans, Chris, Bult, Wouter, Bos, Mariska, Storm, Gert, Nijsen, J. Frank W, Hennink, Wim E
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Biochemistry
Biological and medical sciences
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedical materials
Biomedicine
Cancer
Clinical Trials as Topic
Drug Delivery Systems
Expert Review
General pharmacology
Humans
image analysis
Medical Law
Medical sciences
Micelles
Molecular biology
nanomedicine
Neoplasms - drug therapy
Pharmaceutical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacy
Polymers
theranostics
triggered release
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Summary:Micelles are colloidal particles with a size around 5-100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet' a major step forward.
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-010-0233-4