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cell biology of polycystic kidney disease

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease, which is attributable to mutations in the PKD1 and PKD2 genes and which is characterized by perturbations of renal epitheli...

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Published in:	The Journal of cell biology 2010-11, Vol.191 (4), p.701-710
Main Authors:	Chapin, Hannah C, Caplan, Michael J
Format:	Article
Language:	English
Subjects:	Animals Autosomal dominant polycystic kidney Autosomal recessive polycystic kidney Cell growth Cellular biology Cilia Cystic kidney diseases Cysts Gene expression Genetic disorders GTP-Binding Proteins - metabolism Humans Kidney - pathology Kidney - physiopathology Kidney diseases Kidneys Models, Molecular Mutation Pathogenesis Polycystic kidney diseases Polycystic Kidney, Autosomal Dominant - genetics Polycystic Kidney, Autosomal Dominant - pathology Polycystic Kidney, Autosomal Dominant - physiopathology Proteins Review Reviews Signal Transduction - physiology TRPP cation channels TRPP Cation Channels - chemistry TRPP Cation Channels - genetics TRPP Cation Channels - metabolism Wnt Proteins - metabolism
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description	Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease, which is attributable to mutations in the PKD1 and PKD2 genes and which is characterized by perturbations of renal epithelial cell growth control, fluid transport, and morphogenesis. The mechanisms that connect the underlying genetic defects to disease pathogenesis are poorly understood, but their exploration is shedding new light on interesting cell biological processes and suggesting novel therapeutic targets.
doi_str_mv	10.1083/jcb.201006173
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subjects	Animals Autosomal dominant polycystic kidney Autosomal recessive polycystic kidney Cell growth Cellular biology Cilia Cystic kidney diseases Cysts Gene expression Genetic disorders GTP-Binding Proteins - metabolism Humans Kidney - pathology Kidney - physiopathology Kidney diseases Kidneys Models, Molecular Mutation Pathogenesis Polycystic kidney diseases Polycystic Kidney, Autosomal Dominant - genetics Polycystic Kidney, Autosomal Dominant - pathology Polycystic Kidney, Autosomal Dominant - physiopathology Proteins Review Reviews Signal Transduction - physiology TRPP cation channels TRPP Cation Channels - chemistry TRPP Cation Channels - genetics TRPP Cation Channels - metabolism Wnt Proteins - metabolism
title	cell biology of polycystic kidney disease
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