Cardiac Progenitor Cells and Bone Marrow-Derived Very Small Embryonic-Like Stem Cells for Cardiac Repair After Myocardial Infarction

Heart failure after myocardial infarction (MI) continues to be the most prevalent cause of morbidity and mortality worldwide. Although pharmaceutical agents and interventional strategies have contributed greatly to therapy, new and superior treatment modalities are urgently needed given the overall...

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Bibliographic Details
Published in:Circulation Journal 2010, Vol.74(3), pp.390-404
Main Authors: Tang, Xian-Liang, Rokosh, D. Gregg, Guo, Yiru, Bolli, Roberto
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - cytology
Cardiac function
Cell Size
Cells
Ischemic heart disease
Heart Function Tests
Humans
Myocardial infarction
Myocardial Infarction - pathology
Myocardial Infarction - therapy
Myocytes, Cardiac - cytology
Recovery of Function
Regeneration
Reperfusion
Stem Cell Transplantation
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Summary:Heart failure after myocardial infarction (MI) continues to be the most prevalent cause of morbidity and mortality worldwide. Although pharmaceutical agents and interventional strategies have contributed greatly to therapy, new and superior treatment modalities are urgently needed given the overall disease burden. Stem cell-based therapy is potentially a promising strategy to lead to cardiac repair after MI. An array of cell types has been explored in this respect, including skeletal myoblasts, bone marrow (BM)-derived stem cells, embryonic stem cells, and more recently, cardiac progenitor cells (CPCs). Recently studies have obtained evidence that transplantation of CPCs or BM-derived very small embryonic-like stem cells can improve cardiac function and alleviate cardiac remodeling, supporting the potential therapeutic utility of these cells for cardiac repair. This report summarizes the current data from those studies and discusses the potential implication of these cells in developing clinically-relevant stem cell-based therapeutic strategies for cardiac regeneration. (Circ J 2010; 74: 390 - 404)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-09-0923