The effects of photodynamic therapy in upper-gastrointestinal malignant diseases

Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and...

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Bibliographic Details
Published in:Gut and liver 2010-09, Vol.4 Suppl 1 (Suppl.1), p.S39-S43
Main Authors: Kim, Key Hyeon, Park, Jong-Jae
Format: Article
Language:English
Subjects:
Alimentary Tract
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Summary:Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.
ISSN:1976-2283
2005-1212
DOI:10.5009/gnl.2010.4.S1.S39