Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice

We used a heterogeneous stock of mice—UM-HET3, the first generation offspring of CByB6F1/J and C3D2F1/J parents—to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, we observed essentially the same in...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2010-12, Vol.65A (12), p.1275-1284
Main Authors: Flurkey, Kevin, Astle, Clinton M., Harrison, David E.
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Amino acids
Animal populations
Animals
Antiaging interventions
Aspirin - pharmacology
Crosses, Genetic
Diet
Diet restriction
Female
Flurbiprofen - analogs & derivatives
Flurbiprofen - pharmacology
Genetics
HET3
Imines - pharmacology
Journal of Gerontology: BIOLOGICAL SCIENCES
Life cycles
Life Expectancy
Life span
Longevity - drug effects
Male
Masoprocol - pharmacology
Mice
Mice, Inbred Strains - genetics
Phenols - pharmacology
Proteins
Rodents
Sex Factors
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Summary:We used a heterogeneous stock of mice—UM-HET3, the first generation offspring of CByB6F1/J and C3D2F1/J parents—to test effects of six antiaging treatments on life span. In the first report of diet restriction in a structured, segregating heterogeneous population, we observed essentially the same increases in mean and maximum life span as found in CByB6F1/J hybrid positive controls. We also report results of treatment with N-acetyl-L-cysteine started at 7 months, and aspirin, nitroflurbiprofen, 4-hydroxy phenyl N-tert-butyl nitrone, and nordihydroguaiaretic acid, all started at 16–18 months. Only male UM-HET3 mice receiving N-acetyl-L-cysteine had significantly increased life span, and this may have been due to treatment-related inadvertent diet restriction. The other agents had no significant effects on life span. The use of UM-HET3 mice helps assure that these results are not the result of unresponsiveness of a single genotype but that they more broadly represent laboratory mice.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glq155