A phase II study of weekly docetaxel and cisplatin plus oral tegafur/uracil and leucovorin as first-line chemotherapy in patients with locally advanced or metastatic gastric cancer

• Published in: British journal of cancer 2010-10, Vol.103 (9), p.1343-1348
• Main Authors: Li, C-P, Chen, J-S, Chen, L-T, Yen, C-J, Lee, K-D, Su, W-P, Lin, P-C, Lu, C-H, Tsai, H-J, Chao, Y
• Format: Article
• Language: English
• Subjects: 631/154/436/108; 692/699/67/1504/1829; 692/700/565/1436/1437; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cisplatin - administration & dosage; Clinical Study; Drug Administration Schedule; Drug Resistance; Epidemiology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Leucovorin - administration & dosage; Medical sciences; Middle Aged; Molecular Medicine; Neoplasm Metastasis; Oncology; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Taxoids - administration & dosage; Tegafur - administration & dosage; Tumors; Uracil - therapeutic use
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/sj.bjc.6605928

Background: Docetaxel plus cisplatin and 5-fluorouracil has become a new standard for treating advanced gastric cancer. However, high rates of severe neutropenia limit its application. Modification of the regimen could be the solution to get similar activity but less myelosuppression. Methods: Patients with histologically confirmed, locally advanced, or recurrent/metastatic gastric adenocarcinoma without previous chemotherapy were enrolled. This regimen consisted of docetaxel (Tyxan, TTY, Taipei, Taiwan) 30-min infusion at a dose of 36 mg m −2 , followed by cisplatin 30 mg m −2 infusion over 1 h on days 1 and 8, and oral tegafur/uracil 300 mg m −2 per day plus leucovorin 90 mg per day on days 1–14, every 3 weeks. Tumour response was evaluated after every 2 cycles of treatment. Results: From August 2007 to March 2009, 45 patients were enrolled. The median age was 56 years (range: 22–75). Among the 40 patients evaluable for tumour response, one achieved a complete response, 22 had partial responses and 11 had stable disease. The overall response rates of the evaluable and intent-to-treat (ITT) populations were 58% (95% CI: 41–74%) and 53% (95% CI: 38–68%), respectively. The disease control rates in these populations were 85% (95% CI: 70–94%) and 82% (95% CI: 68–92%), respectively. In the ITT analysis, the median time to progression and overall survival were 6.8 and 13.9 months, respectively. Major grade 3–4 toxicities were neutropenia (51%), anaemia (22%), diarrhoea (16%), and infections (20%). No patient died of treatment-related toxicities. Conclusion: Concurrent weekly docetaxel and cisplatin plus oral tegafur/uracil and leucovorin are effective and well tolerated in the treatment of advanced gastric cancer.