Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus

Research highlights ► SDR, a model of social defeat, significantly influences immunogenic DCs. ► Adoptively transferred DCs from SDR mice enhance adaptive immunity to influenza. ► SDR DC recipients have increased Db NP366-74 CD8+ T cells in the lung after infection. ► SDR DC recipients have increase...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2011-01, Vol.25 (1), p.46-52
Main Authors: Powell, Nicole D, Mays, Jacqueline W, Bailey, Michael T, Hanke, Mark L, Sheridan, John F
Format: Article
Language:English
Subjects:
Adaptive Immunity - immunology
Allergy and Immunology
Animals
Antigens, Viral - immunology
CD11 Antigens - immunology
CD8 + T cells
CD8-Positive T-Lymphocytes - immunology
Cell Count
Competitive Behavior - physiology
Dendritic cell
Dendritic Cells - immunology
Epitopes - immunology
Flow Cytometry
Immunologic Memory
Influenza A
Influenza A virus
Influenza A virus - immunology
Interferon-alpha - biosynthesis
Interferon-gamma - biosynthesis
Male
Mice
Mice, Inbred C57BL
Psychiatry
Reverse Transcriptase Polymerase Chain Reaction
Social disruption stress
Social Dominance
Social Environment
Stress, Psychological - immunology
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Summary:Research highlights ► SDR, a model of social defeat, significantly influences immunogenic DCs. ► Adoptively transferred DCs from SDR mice enhance adaptive immunity to influenza. ► SDR DC recipients have increased Db NP366-74 CD8+ T cells in the lung after infection. ► SDR DC recipients have increased IFN-α and IFN-γ mRNA in the lung after infection. ► SDR DC recipients have decreased M1 mRNA in the lung after infection.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2010.07.243