Large B-cell lymphoma with an unusual infiltrating pattern: report of two cases

Large B-cell lymphoma presents with the most varied infiltrating patterns and morphologies. Here we report two cases of unusual large B-cell lymphoma in two old female patients. Both lymphomas show: 1) scattered and clustered large B-cells infiltrating the periphery of polyclonal lymphoid nodules; 2...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2010-10, Vol.3 (8), p.815-821
Main Authors: Haycocks, Neil G, Zhao, X Frank
Format: Article
Language:English
Subjects:
Aged
B-Lymphocytes - metabolism
B-Lymphocytes - pathology
Case Report
Combined Modality Therapy
DNA, Neoplasm - analysis
Fatal Outcome
Female
Humans
Lymph Nodes - blood supply
Lymph Nodes - pathology
Lymphoma, Large B-Cell, Diffuse - metabolism
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Large B-Cell, Diffuse - therapy
Muscle, Skeletal - pathology
Neoplasm Invasiveness
Neoplasm, Residual
Neovascularization, Pathologic
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Summary:Large B-cell lymphoma presents with the most varied infiltrating patterns and morphologies. Here we report two cases of unusual large B-cell lymphoma in two old female patients. Both lymphomas show: 1) scattered and clustered large B-cells infiltrating the periphery of polyclonal lymphoid nodules; 2) large B-cells with an immunoblastic morphology; 3) large B-cell infiltration associated with vascular proliferation; 4) coexisting lymphoid nodules with hyaline vascular proliferation. The first case took an aggressive clinical course with transformation into acute leukemia, and imparted a short patient survival, whereas the second case responded to chemotherapy, experienced a local recurrence and long survival for >7 years. To our knowledge, these are the first reported cases of large B-cell lymphomas with a paranodular infiltrating pattern, immunoblastic morphology, and associated vascular proliferation.
ISSN:1936-2625