Large B-cell lymphoma with an unusual infiltrating pattern: report of two cases

• Published in: International journal of clinical and experimental pathology 2010-10, Vol.3 (8), p.815-821
• Main Authors: Haycocks, Neil G, Zhao, X Frank
• Format: Article
• Language: English
• Subjects: Aged; B-Lymphocytes - metabolism; B-Lymphocytes - pathology; Case Report; Combined Modality Therapy; DNA, Neoplasm - analysis; Fatal Outcome; Female; Humans; Lymph Nodes - blood supply; Lymph Nodes - pathology; Lymphoma, Large B-Cell, Diffuse - metabolism; Lymphoma, Large B-Cell, Diffuse - pathology; Lymphoma, Large B-Cell, Diffuse - therapy; Muscle, Skeletal - pathology; Neoplasm Invasiveness; Neoplasm, Residual; Neovascularization, Pathologic
• ISSN: 1936-2625

Large B-cell lymphoma presents with the most varied infiltrating patterns and morphologies. Here we report two cases of unusual large B-cell lymphoma in two old female patients. Both lymphomas show: 1) scattered and clustered large B-cells infiltrating the periphery of polyclonal lymphoid nodules; 2) large B-cells with an immunoblastic morphology; 3) large B-cell infiltration associated with vascular proliferation; 4) coexisting lymphoid nodules with hyaline vascular proliferation. The first case took an aggressive clinical course with transformation into acute leukemia, and imparted a short patient survival, whereas the second case responded to chemotherapy, experienced a local recurrence and long survival for >7 years. To our knowledge, these are the first reported cases of large B-cell lymphomas with a paranodular infiltrating pattern, immunoblastic morphology, and associated vascular proliferation.