Genetic Linkage Map of Human Chromosome 7 with 63 DNA Markers

High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregati...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1987-11, Vol.84 (22), p.8006-8010
Main Authors: Barker, David, Green, Philip, Knowlton, Robert, Schumm, James, Lander, Eric, Oliphant, Arnold, Willard, Huntington, Akots, Gita, Brown, Valerie, Gravius, Thomas, Helms, Cynthia, Nelson, Christopher, Parker, Carol, Rediker, Kenneth, Rising, Marcia, Watt, Diane, Weiffenbach, Barbara, Donis-Keller, Helen
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 7
DNA
DNA probes
DNA, Recombinant
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Genetic diseases
Genetic Linkage
Genetic loci
Genetic mapping
Genetic Markers
Humans
Libraries
Medical genetics
Molecular and cellular biology
Molecular genetics
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
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Summary:High-density genetic maps of individual human chromosomes will permit accurate localization of disease-associated genes and provide signposts that will be useful in the construction of physical maps. We have constructed a genetic map of chromosome 7 with 63 polymorphic DNA markers by using segregation data from 23 three-generation families and recently developed multilocus linkage-analysis techniques. The map spans 250 centimorgans in females and 170 centimorgans in males, with much of the difference being concentrated in a few intervals. The density and informativeness of the markers are such that there is a high probability of detecting linkage to any disease gene on this chromosome for which 20 phase-known meioses are available.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.84.22.8006