Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

Abstract The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation...

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Bibliographic Details
Published in:Journal of neuroimmunology 2009-01, Vol.206 (1), p.121-124
Main Authors: Zhang, Rongzhen, Miller, Robert G, Gascon, Ron, Champion, Stacey, Katz, Jonathan, Lancero, Mariselle, Narvaez, Amy, Honrada, Ronald, Ruvalcaba, David, McGrath, Michael S
Format: Article
Language:English
Subjects:
Aged
Allergy and Immunology
Alzheimer Disease - blood
Amyotrophic lateral sclerosis (ALS)
Amyotrophic Lateral Sclerosis - blood
Amyotrophic Lateral Sclerosis - immunology
Amyotrophic Lateral Sclerosis - pathology
Analysis of Variance
Endotoxins - blood
Female
Flow Cytometry - methods
HLA-DR Antigens - metabolism
Humans
Interleukin-10 - metabolism
Lipopolysaccharide (LPS)
Lipopolysaccharides - blood
Macrophages - immunology
Macrophages - metabolism
Male
Middle Aged
Monocyte/macrophage activation
Monocytes - immunology
Monocytes - metabolism
Neurology
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Summary:Abstract The present study reports elevated levels of endotoxin/lipopolysaccharide (LPS) concentrations in plasma from patients with sporadic amyotrophic lateral sclerosis (sALS) and Alzheimer's (AD) as compared to healthy controls. Levels of plasma LPS showed a significant positive correlation with degree of blood monocyte/macrophage activation in disease groups and was most elevated in patients with advanced sALS disease. There was a significant negative relationship between plasma LPS and levels of monocyte/macrophage IL-10 expression in sALS blood. These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2008.09.017