In vivo biocompatibility study of electrospun chitosan microfiber for tissue engineering

In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantatio...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2010-10, Vol.11 (10), p.4140-4148
Main Authors: Kang, Yun Mi, Lee, Bit Na, Ko, Jae Hoon, Kim, Gyeong Hae, Kang, Kkot Nim, Kim, Da Yeon, Kim, Jae Ho, Park, Young Hwan, Chun, Heung Jae, Kim, Chun Ho, Kim, Moon Suk
Format: Article
Language:English
Subjects:
Aluminum
Animals
Biocompatibility
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Chitosan - chemistry
Chitosan - pharmacology
Collagen
Electronic mail systems
Myoblasts - cytology
Myoblasts - drug effects
Rats
Stem Cell Transplantation
Stem cells
Tissue Engineering
Tissue Scaffolds - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms11104140