Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects

The circuit changes that mediate parkinsonian tremor, while likely differing from those underlying akinesia and rigidity, are not precisely known. In this study, to identify a specific metabolic brain network associated with this disease manifestation, we used FDG PET to scan nine tremor dominant Pa...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2011-01, Vol.54 (2), p.1244-1253
Main Authors: Mure, Hideo, Hirano, Shigeki, Tang, Chris C., Isaias, Ioannis U., Antonini, Angelo, Ma, Yilong, Dhawan, Vijay, Eidelberg, David
Format: Article
Language:English
Subjects:
Aged
Akinesia
Basal ganglia
Brain - diagnostic imaging
Brain research
Central nervous system diseases
Cerebellum
Cortex (motor)
Deep Brain Stimulation
Dentate nucleus
Disease Progression
Electrical stimuli
Female
Fluorodeoxyglucose F18
Humans
Male
Medical imaging
Medical treatment
Metabolic networks
Metabolism
Middle Aged
Movement disorders
Neurodegenerative diseases
Parkinson Disease - complications
Parkinson Disease - diagnostic imaging
Parkinson Disease - therapy
Parkinson's disease
Patients
Positron emission tomography
Putamen
Radiopharmaceuticals
Ratings & rankings
Solitary tract nucleus
STN DBS
Subthalamic nucleus
Thalamus
Tremor
Tremor (Muscular contraction)
Tremor - diagnostic imaging
Tremor - etiology
Tremor - therapy
Vim DBS
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Summary:The circuit changes that mediate parkinsonian tremor, while likely differing from those underlying akinesia and rigidity, are not precisely known. In this study, to identify a specific metabolic brain network associated with this disease manifestation, we used FDG PET to scan nine tremor dominant Parkinson's disease (PD) patients at baseline and during ventral intermediate (Vim) thalamic nucleus deep brain stimulation (DBS). Ordinal trends canonical variates analysis (OrT/CVA) was performed on the within-subject scan data to detect a significant spatial covariance pattern with consistent changes in subject expression during stimulation-mediated tremor suppression. The metabolic pattern was characterized by covarying increases in the activity of the cerebellum/dentate nucleus and primary motor cortex, and, to a less degree, the caudate/putamen. Vim stimulation resulted in consistent reductions in pattern expression (p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2010.09.028