Heart regeneration:Past,present and future

The heart has been considered a post-mitotic organ without regenerative capacity for most of the last century.We review the evidence that led to this hypothesis in the early 1900s and how it was progressively modified,culminating with the report that we renew 50% of our cardiomyocytes during our lif...

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Bibliographic Details
Published in:World journal of cardiology 2010-05, Vol.2 (5), p.107-111
Main Authors: Carvalho, Adriana Bastos, de Carvalho, Antonio Carlos Campos
Format: Article
Language:English
Subjects:
Cardiac
Cardiomyocyte
cell-based
cells
proliferation
Self-renewal
stem
therapies
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Summary:The heart has been considered a post-mitotic organ without regenerative capacity for most of the last century.We review the evidence that led to this hypothesis in the early 1900s and how it was progressively modified,culminating with the report that we renew 50% of our cardiomyocytes during our lifetime.The future of cardiac regenerative therapies is discussed,presenting the difficulties to overcome before repair of the diseased heart can come into clinical practice.
ISSN:1949-8462
1949-8462
DOI:10.4330/wjc.v2.i5.107