Vascular endothelial growth factor,p53,and the H-ras oncogene in Egyptian patients with bladder cancer

AIM:To evaluate the relationship between vascular endothelial growth factor(VEGF),p53,and the H-ras oncogene and different clinicopathological parameters in Egyptian patients with Schistosoma-associated transitional cell carcinoma of the bladder.METHODS:The study included 50 patients with transition...

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Published in:World journal of gastrointestinal oncology 2009-10, Vol.1 (1), p.62-68
Main Authors: El-Chennawi, Farha A, Auf, Fatma A, Metwally, Shereen S, Mosaad, Youssef M, Shaaban, Atallah A, El-Baz, Mahmoud Abdo, Tawhid, Ziyad E, Lotfy, Zakaria F
Format: Article
Language:English
Subjects:
Bladder
Brief
cancer
carcinoma
cell
endothelial
factor
growth
H-ras
oncogene
p53
Transitional
Vascular
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Summary:AIM:To evaluate the relationship between vascular endothelial growth factor(VEGF),p53,and the H-ras oncogene and different clinicopathological parameters in Egyptian patients with Schistosoma-associated transitional cell carcinoma of the bladder.METHODS:The study included 50 patients with transitional cell carcinoma for whom radical cystectomy and urinary diversions were carried out.VEGF and p53 protein expressions were evaluated with an immunohistochemical staining method,and H-ras oncogene mutations were analyzed with a polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique.RESULTS:High grade tumors revealed higher p53 immunostaining than low grade tumors(P = 0.016).p53 and VEGF protein expressions,as well as H-ras oncogene mutations,had an insignificant impact on patient outcomes(P = 0.962,P = 0.791,and P = 967,respectively).Cancer extension to regional lymph nodes was associated with poor outcomes(P = 0.008).CONCLUSION:VEGF,p53 and the H-ras oncogene have no relation to patient survival and outcome in Schistosoma-associated transitional cell carcinoma.
ISSN:1948-5204
1948-5204
DOI:10.4251/wjgo.v1.i1.62