The ABC of clinical and experimental adjuvants—A brief overview

Abstract Adjuvants are compounds that can increase and/or modulate the intrinsic immunogenicity of an antigen and elicit strong and long lasting immune responses. During the last 80 years many adjuvants have been used in experimental settings, but due to various shortcomings of most of them only alu...

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Bibliographic Details
Published in:Immunology letters 2010-01, Vol.128 (1), p.29-35
Main Authors: Brunner, Richard, Jensen-Jarolim, Erika, Pali-Schöll, Isabella
Format: Article
Language:English
Subjects:
Adjuvant
Adjuvants, Immunologic - pharmacology
Adjuvants, Immunologic - therapeutic use
Allergy and Immunology
Aluminum
Aluminum Compounds - immunology
Aluminum Compounds - therapeutic use
Animals
Bacterial Toxins - immunology
Cholera toxin B
Flagellin
Flagellin - immunology
Freund's Adjuvant - immunology
Freund’s adjuvant
Humans
Immune response
Lipid A - analogs & derivatives
Lipid A - immunology
MF59
Monophosphoryl lipid A
Nanoparticles
Poly-lactid-co-glycolid acid
Polysorbates
Squalene - immunology
Vaccines
Virosomes
Virosomes - immunology
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Summary:Abstract Adjuvants are compounds that can increase and/or modulate the intrinsic immunogenicity of an antigen and elicit strong and long lasting immune responses. During the last 80 years many adjuvants have been used in experimental settings, but due to various shortcomings of most of them only aluminum compounds made it into regular clinical usage. However, during the last years promising candidates have arisen that may finally adjunct or displace aluminum substances as main adjuvant. This review summarizes information on adjuvants currently used in clinical as well as in experimental settings.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2009.10.005