NOD-like receptor (NLR) signaling beyond the inflammasome

Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert importan...

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Bibliographic Details
Published in:European journal of immunology 2010-03, Vol.40 (3), p.624-627
Main Authors: Shaw, Patrick J, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Format: Article
Language:English
Subjects:
Animals
Humans
Inflammasome
Inflammation - immunology
Innate immunity
Multiprotein Complexes - immunology
NLR
Nod Signaling Adaptor Proteins - immunology
Signal Transduction - immunology
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Summary:Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.200940211