Toll-like receptor 9 gene mutations and polymorphisms in Japanese ulcerative colitis patients

To investigated gene mutations and polymorphisms of TLR9 in Japanese ulcerative colitis (UC) patients. Three single nucleotide polymorphisms (SNPs) in TLR9 were identified in healthy controls, and were assessed in 48 UC patients and 47 healthy controls. Control subjects were matched for age, sex and...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2010-12, Vol.16 (46), p.5815-5821
Main Authors: Fuse, Kaori, Katakura, Kyoko, Sakamoto, Natsumi, Ohira, Hiromasa
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - genetics
Colitis, Ulcerative - genetics
Colitis, Ulcerative - physiopathology
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Mutation
Original
Phenotype
Polymorphism, Single Nucleotide
Toll-Like Receptor 9 - genetics
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Summary:To investigated gene mutations and polymorphisms of TLR9 in Japanese ulcerative colitis (UC) patients. Three single nucleotide polymorphisms (SNPs) in TLR9 were identified in healthy controls, and were assessed in 48 UC patients and 47 healthy controls. Control subjects were matched for age, sex and date of blood sampling from among a subgroup of participants. TLR9 -1486CC, 1174GG and 2848AA increase the risk of UC [odds ratio (OR) 2.64, 95% confidence interval (95% CI): 1.73-6.53, P = 0.042], and TLR9 -1486TT, 1174AA and 2848GG decrease the risk of UC (OR 0.30, 95% CI: 0.10-0.94, P = 0.039), although there were no correlations between SNPs and disease phenotype or TLR9 mRNA expression. TLR9 polymorphisms are associated with increased susceptibility to UC.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i46.5815