Chronic Myeloid Leukemia Presenting with Visual and Auditory Impairment in an Adolescent: An Insight to Management Strategies

A 15-year-old girl presented with progressive deterioration in vision and hearing over 1 week. A huge spleen was palpated below the left costal margin laying down to inguinal region. Blood count showed hyperleukocytosis with a white blood cell count of 455 × 10 9 /l. Peripheral smear yielded myeloid...

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Bibliographic Details
Published in:Indian journal of hematology & blood transfusion 2010-09, Vol.26 (3), p.96-98
Main Authors: Gokce, Muge, Unal, Sule, Bayrakçı, Benan, Tuncer, Murat
Format: Article
Language:English
Subjects:
Blood Transfusion Medicine
Case Report
Hematology
Human Genetics
Medicine
Medicine & Public Health
Oncology
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Summary:A 15-year-old girl presented with progressive deterioration in vision and hearing over 1 week. A huge spleen was palpated below the left costal margin laying down to inguinal region. Blood count showed hyperleukocytosis with a white blood cell count of 455 × 10 9 /l. Peripheral smear yielded myeloid precursor cells with basophilia. Bone marrow aspiration revealed a blast count of 5% morphologically and 4% by flow cytometry. Fundoscopic examination revealed bilateral retinal exudates, edema and hemorhages. Partial sensorioneural hearing loss was also detected on the right ear. The diagnosis of chronic myeloid leukemia was confirmed by positive t(9;22) by RT-PCR. After commencing on hydroxyurea and intrathecal methotrexate-prednisolone, progressive improvement in hearing and vision was obtained. In our brief report, we aimed to emphasize rare presentation with visual and hearing impairment of chronic myeloid leukemia during childhood, especially in “ chronic phase ”.
ISSN:0971-4502
0974-0449
DOI:10.1007/s12288-010-0026-2