SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended?

SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Di...

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Bibliographic Details
Published in:Arthritis research & therapy 2009-01, Vol.11 (6), p.131-131
Main Author: Rozin, Alexander P
Format: Article
Language:English
Subjects:
Acquired Hyperostosis Syndrome - drug therapy
Acquired Hyperostosis Syndrome - immunology
Acquired Hyperostosis Syndrome - microbiology
Animals
Anti-Bacterial Agents - therapeutic use
Antirheumatic Agents - therapeutic use
Humans
Propionibacterium acnes - immunology
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Summary:SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assmann et al. is a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Randomized control studies are needed to confirm the effects of antibiotic therapy.
ISSN:1478-6354
1478-6362
DOI:10.1186/ar2837