A rare cause of precocious puberty: hepatoblastoma

Hepatoblastoma, an embryonal tumor, is one of the most common primary liver tumors in childhood. It secretes human chorionic gonadotropin (hCG), which can cause precocious puberty (PP). Herein, we present a case with PP who had enlarged penile size noticed during a diagnosis of hepatoblastoma. Labor...

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Bibliographic Details
Published in:Journal of clinical research in pediatric endocrinology 2009-12, Vol.1 (6), p.281-283
Main Authors: Eren, Erdal, Demirkaya, Metin, Çakır, Esra D Papatya, Sevinir, Betül, Sağlam, Halil, Tarım, Ömer
Format: Article
Language:English
Subjects:
Case Reports
Child, Preschool
Hepatoblastoma - complications
Humans
Liver Neoplasms - complications
Male
Puberty, Precocious - etiology
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Summary:Hepatoblastoma, an embryonal tumor, is one of the most common primary liver tumors in childhood. It secretes human chorionic gonadotropin (hCG), which can cause precocious puberty (PP). Herein, we present a case with PP who had enlarged penile size noticed during a diagnosis of hepatoblastoma. Laboratory examination revealed increased testosterone, alpha-fetoprotein (AFP), and hCG levels. Serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were within prepubertal ranges. The diagnosis of hepatoblastoma was made by liver biopsy. Chemotherapy was administered, and the patient was referred to surgery. Ten months later, testis volumes were below 4 ml bilaterally, and penile length was 5.5 cm. Serum testosterone, AFP, and hCG levels decreased. Resection of the tumor and chemotherapy are essential for the treatment of hepatoblastoma and they can eliminate the symptoms of PP.
ISSN:1308-5727
1308-5735
DOI:10.4274/jcrpe.v1i6.281