Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification

Transcription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences. JDP2 plays a key role as a repressor of adipocyte different...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2011-01, Vol.2011 (2011), p.1-13
Main Authors: Hasegawa, Hitomi, Huang, Yu-Chang, Wang, Shin-Wei, Ku, Chia-Chen, Lin, Ying-Chu, Chiou, Shyh-Shin, Hou, Ming-Feng, Wu, Deng-Chyang, Tsai, Eing-Mei, Saito, Shigeo, Yamaguchi, Naoto, Yokoyama, Kazunari K.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Differentiation - physiology
Cellular Senescence - physiology
Chromatin
DNA methylation
Genetics
Histones
Histones - physiology
Humans
Kinases
Medicine
Methylation
Mice
Oxidative stress
Phosphorylation
Physiological aspects
Preventive medicine
Proteins
Repressor Proteins - physiology
Review
Tumor suppressor genes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transcription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core histones and of reconstituted nucleosomes that contain JDP2 recognition DNA sequences. JDP2 plays a key role as a repressor of adipocyte differentiation by regulation of the expression of the gene C/EBPδ via inhibition of histone acetylation. Moreover, JDP2-deficient mouse embryonic fibroblasts (JDP2−/− MEFs) are resistant to replicative senescence. JDP2 inhibits the recruitment of polycomb repressive complexes (PRC1 and PRC2) to the promoter of the gene encoding p16Ink4a, resulting from the inhibition of methylation of lysine 27 of histone H3 (H3K27). Therefore, it seems that chromatin-remodeling factors, including the PRC complex controlled by JDP2, may be important players in the senescence program. The novel mechanisms that underline the action of JDP2 in inducing cellular senescence and suppressing adipocyte differentiation are reviewed.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2011/569034