The structure of the Escherichia coli O148 lipopolysaccharide core region and its linkage to the O-specific polysaccharide

Recently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a gluco...

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Bibliographic Details
Published in:Carbohydrate research 2011-01, Vol.346 (1), p.150-152
Main Authors: Kubler-Kielb, Joanna, Lai, Wen-Tzu, Schneerson, Rachel, Vinogradov, Evgeny
Format: Article
Language:English
Subjects:
Carbohydrate Sequence
Core
Escherichia coli
Escherichia coli - chemistry
Escherichia coli O148
galactose
glucose
glycosidic linkages
lipopolysaccharides
Lipopolysaccharides - chemistry
LPS
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Sequence Data
O Antigens - chemistry
O-Specific polysaccharide
Shigella dysenteriae
Structure
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Summary:Recently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a glucose residue in E. coli O148. Herein, we analyzed the core structure and its linkage to the O-SP in E. coli O148 LPS. Both were found to be identical to those of S. dysenteriae type 1 structures, further supporting the relatedness of these two bacteria. The following structure of the core with one repeat unit of the O-SP has been assigned (all have d-configuration except l-Rha): ▪
ISSN:0008-6215
1873-426X
DOI:10.1016/j.carres.2010.10.012