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In vivo effects of zoledronic acid on oral mucosal epithelial cells

Oral Diseases (2011) 17, 291–297 Objective:  Osteonecrosis of the jaw is a serious complication of bisphosphonate treatment for which the pathophysiology is unknown. The purpose of this study was to investigate whether in vivo zoledronic acid (ZA) induces alterations in cell proliferation, apoptosis...

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Published in:Oral diseases 2011-04, Vol.17 (3), p.291-297
Main Authors: Allam, E, Allen, MR, Chu, T-M, Ghoneima, A, Jack Windsor, L
Format: Article
Language:English
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Summary:Oral Diseases (2011) 17, 291–297 Objective:  Osteonecrosis of the jaw is a serious complication of bisphosphonate treatment for which the pathophysiology is unknown. The purpose of this study was to investigate whether in vivo zoledronic acid (ZA) induces alterations in cell proliferation, apoptosis, and matrix metalloproteinases (MMPs) expression in oral mucosal epithelial cells. Methods:  One‐year‐old dogs were either untreated (control group) or given high doses of intravenous ZA (ZA group) for 3 months. The doses of ZA were equivalent to those given to cancer patients, yet were administered two times more frequently (every 2 weeks). Mucosal tissues were assessed immunohistochemically for cell proliferation (proliferating cell nuclear antigen, PCNA), matrix metalloproteinase (MMP) expression, and apoptosis (caspase 3 and TUNEL). Results:  There were no significant differences between the groups with respect to PCNA, MMP‐2, MMP‐14, and TUNEL positive cells. However, the expression of MMP‐9 was significantly higher in the control group than in the ZA group (P 
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2010.01739.x