Response Surface Methodology to Optimize Novel Fast Disintegrating Tablets Using β Cyclodextrin as Diluent

The objective of this work was to apply response surface approach to investigate main and interaction effects of formulation parameters in optimizing novel fast disintegrating tablet formulation using β cyclodextrin as a diluent. The variables studied were diluent (β cyclodextrin, X 1 ), superdisint...

Full description

Saved in:
Bibliographic Details
Published in:AAPS PharmSciTech 2010-12, Vol.11 (4), p.1627-1635
Main Authors: Late, Sameer G., Banga, Ajay K.
Format: Article
Language:English
Subjects:
Antiemetics - chemistry
beta-Cyclodextrins - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Carboxymethylcellulose Sodium - chemistry
Dosage Forms
Drug Compounding
Drug Delivery Systems
Excipients - chemistry
Granisetron - chemistry
Hardness
Lactose - chemistry
Pharmacology/Toxicology
Pharmacy
Reproducibility of Results
Research Article
Solubility
Tablets
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this work was to apply response surface approach to investigate main and interaction effects of formulation parameters in optimizing novel fast disintegrating tablet formulation using β cyclodextrin as a diluent. The variables studied were diluent (β cyclodextrin, X 1 ), superdisintegrant (Croscarmellose sodium, X 2 ), and direct compression aid (Spray dried lactose, X 3 ). Tablets were prepared by direct compression method on B2 rotary tablet press using flat plain-face punches and characterized for weight variation, thickness, disintegration time ( Y 1 ), and hardness ( Y 2 ). Disintegration time was strongly affected by quadratic terms of β cyclodextrin, croscarmellose sodium, and spray-dried lactose. The positive value of regression coefficient for β cyclodextrin suggested that hardness increased with increased amount of β cyclodextrin. In general, disintegration of tablets has been reported to slow down with increase in hardness. However in the present study, higher concentration of β cyclodextrin was found to improve tablet hardness without increasing the disintegration time. Thus, β cyclodextrin is proposed as a suitable diluent to achieve fast disintegrating tablets with sufficient hardness. Good correlation between the predicted values and experimental data of the optimized formulation validated prognostic ability of response surface methodology in optimizing fast disintegrating tablets using β cyclodextrin as a diluent.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-010-9541-6