Kidney Stones Associate with Increased Risk for Myocardial Infarction

Kidney stones are a risk factor for chronic kidney disease (CKD), which, in turn, is a risk factor for myocardial infarction (MI). The objective of this study was to determine whether kidney stones associate with an increased risk for MI. We matched 4564 stone formers (1984 through 2003) on age and...

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Bibliographic Details
Published in:Journal of endourology 2010-10, Vol.21 (10), p.1641-1644
Main Authors: RULE, Andrew D, ROGER, Veronique L, MELTON, L. Joseph, BERGSTRALH, Eric J, XUJIAN LI, PEYSER, Patricia A, KRAMBECK, Amy E, LIESKE, John C
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brief Communication
Cardiology. Vascular system
Case-Control Studies
Complications and side effects
Coronary heart disease
Female
Heart
Heart attack
Humans
Kidney Calculi - complications
Kidney Calculi - epidemiology
Kidney stones
Male
Medical sciences
Middle Aged
Minnesota - epidemiology
Myocardial Infarction - epidemiology
Myocardial Infarction - etiology
Nephrology. Urinary tract diseases
Risk Factors
Urinary lithiasis
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Summary:Kidney stones are a risk factor for chronic kidney disease (CKD), which, in turn, is a risk factor for myocardial infarction (MI). The objective of this study was to determine whether kidney stones associate with an increased risk for MI. We matched 4564 stone formers (1984 through 2003) on age and gender with 10,860 control subjects among residents in Olmsted County, Minnesota. We identified incident MI by diagnostic codes and validated events by chart review through 2006. We used diagnostic codes to determine incidence of kidney stones and presence of comorbidities (CKD, hypertension, diabetes, obesity, dyslipidemia, gout, alcohol dependence, and tobacco use). During a mean of 9 years of follow-up, stone formers had a 38% (95% confidence interval 7 to 77%) increased risk for MI, which remained at 31% (95% confidence interval 2% to 69%) after adjustment for CKD and other comorbidities. In conclusion, kidney stone formers are at increased risk for MI, and this risk is independent of CKD and other risk factors.
ISSN:1046-6673
0892-7790
1533-3450
DOI:10.1681/ASN.2010030253