BEZ235 impairs gastric cancer growth by inhibition of PI3K/mTOR in vitro and in vivo

PI3K/mTOR pathway mutations, especially PTEN, PI3K3C and AKT mutations and pS6 overexpression, are found frequently in gastric cancer patients and are linked with poor outcome. [...] we evaluated the dual PI3K and mTOR inhibitor BEZ235 against gastric cancer in vitro and in vivo.

Saved in:
Bibliographic Details
Published in:BMC pharmacology 2010-11, Vol.10 (S1), p.A41-A41, Article A41
Main Authors: Füreder, Thorsten, Wanek, Thomas, Pflegerl, Pamina, Jaeger-Lansky, Agnes, Hoeflmayer, Doris, Strommer, Sabine, Kuntner, Claudia, Müller, Markus, Langer, Oliver, Wacheck, Volker
Format: Article
Language:English
Subjects:
Cancer
Colleges & universities
Kinases
Meeting Abstract
Mutation
Pets
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PI3K/mTOR pathway mutations, especially PTEN, PI3K3C and AKT mutations and pS6 overexpression, are found frequently in gastric cancer patients and are linked with poor outcome. [...] we evaluated the dual PI3K and mTOR inhibitor BEZ235 against gastric cancer in vitro and in vivo.
ISSN:1471-2210
1471-2210
DOI:10.1186/1471-2210-10-S1-A41