Histone Demethylation and Timely DNA Replication

It is well-established that silent regions of the genome replicate late during S phase. In this issue of Molecular Cell, Black et al. (2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9...

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Bibliographic Details
Published in:Molecular cell 2010-12, Vol.40 (5), p.683-684
Main Authors: Gerace, Erica L., Moazed, Danesh
Format: Article
Language:English
Subjects:
Chromatin
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Summary:It is well-established that silent regions of the genome replicate late during S phase. In this issue of Molecular Cell, Black et al. (2010) uncover a conserved role for the JMJD2 family of histone demethylases in promoting replication within silent chromatin regions that contain histone H3 lysine 9 methylation and HP1.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2010.11.036