Musculoskeletal molecular imaging: a comprehensive overview

Molecular imaging permits non-invasive visualization and measurement of molecular and cell biology in living subjects, thereby complementing conventional anatomical imaging. Herein, we review the emerging application of molecular imaging for the study of musculoskeletal biology. Utilizing mainly bio...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2010-02, Vol.28 (2), p.93-101
Main Authors: Reumann, Marie K, Weiser, Mitchell C, Mayer-Kuckuk, Philipp
Format: Article
Language:English
Subjects:
Arthritis
Biological and medical sciences
Biology
Bioluminescence
Biomaterials
Biotechnology
Fluorescence
Fundamental and applied biological sciences. Psychology
Gene expression
Hormones
Humans
Image Processing, Computer-Assisted - methods
Internal Medicine
Investigative techniques, diagnostic techniques (general aspects)
Luminescent Measurements
Medical imaging
Medical sciences
Molecular Imaging - methods
Musculoskeletal Diseases - pathology
Rodents
Studies
Tomography
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Summary:Molecular imaging permits non-invasive visualization and measurement of molecular and cell biology in living subjects, thereby complementing conventional anatomical imaging. Herein, we review the emerging application of molecular imaging for the study of musculoskeletal biology. Utilizing mainly bioluminescence and fluorescence techniques, molecular imaging has enabled in-vivo studies of (i) the activity of osteoblasts, osteoclasts, and hormones, (ii) the mechanisms of pathological cartilage and bone destruction, (iii) skeletal gene and cell therapy with and without biomaterial support, and (iv) the cellular processes in osteolysis and osteomyelitis. In these applications, musculoskeletal molecular imaging demonstrated feasibility for research in a myriad of musculoskeletal conditions ranging from bone fracture and arthritis to skeletal cancer. Importantly, these advances herald great potential for innovative clinical imaging in orthopedics, rheumatology, and oncology.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2009.11.004