Quantification of nanoscale density fluctuations using electron microscopy: Light-localization properties of biological cells

We report a study of the nanoscale mass-density fluctuations of heterogeneous optical dielectric media, including nanomaterials and biological cells, by quantifying their nanoscale light-localization properties. Transmission electron microscope images of the media are used to construct corresponding...

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Published in:Applied physics letters 2010-12, Vol.97 (24), p.243704-243704-3
Main Authors: Pradhan, Prabhakar, Damania, Dhwanil, Joshi, Hrushikesh M., Turzhitsky, Vladimir, Subramanian, Hariharan, Roy, Hemant K., Taflove, Allen, Dravid, Vinayak P., Backman, Vadim
Format: Article
Language:English
Subjects:
Biophysics and Bio-Inspired Systems
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
DENSITY
DIELECTRIC MATERIALS
DISEASES
EIGENFUNCTIONS
EIGENVALUES
ELECTRON MICROSCOPY
FLUCTUATIONS
FUNCTIONS
MASS
MATERIALS
MICROSCOPY
NANOSTRUCTURES
NEOPLASMS
OPTICAL PROPERTIES
PHYSICAL PROPERTIES
TRANSMISSION ELECTRON MICROSCOPY
VARIATIONS
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creator Pradhan, Prabhakar
Damania, Dhwanil
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Turzhitsky, Vladimir
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Dravid, Vinayak P.
Backman, Vadim
description We report a study of the nanoscale mass-density fluctuations of heterogeneous optical dielectric media, including nanomaterials and biological cells, by quantifying their nanoscale light-localization properties. Transmission electron microscope images of the media are used to construct corresponding effective disordered optical lattices. Light-localization properties are studied by the statistical analysis of the inverse participation ratio (IPR) of the localized eigenfunctions of these optical lattices at the nanoscale. We validated IPR analysis using nanomaterials as models of disordered systems fabricated from dielectric nanoparticles. As an example, we then applied such analysis to distinguish between cells with different degrees of aggressive malignancy.
doi_str_mv 10.1063/1.3524523
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subjects Biophysics and Bio-Inspired Systems
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
DENSITY
DIELECTRIC MATERIALS
DISEASES
EIGENFUNCTIONS
EIGENVALUES
ELECTRON MICROSCOPY
FLUCTUATIONS
FUNCTIONS
MASS
MATERIALS
MICROSCOPY
NANOSTRUCTURES
NEOPLASMS
OPTICAL PROPERTIES
PHYSICAL PROPERTIES
TRANSMISSION ELECTRON MICROSCOPY
VARIATIONS
title Quantification of nanoscale density fluctuations using electron microscopy: Light-localization properties of biological cells
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