Analyses of Pediatric Isolates of Cryptococcus neoformans from South Africa

Compared to the incidence in adults, cryptococcosis is inexplicably rare among children, even in sub-Saharan Africa, which has the highest prevalence of coinfection with HIV and Cryptococcus neoformans. To explore any mycological basis for this age-related difference in the incidence of cryptococcos...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2011-01, Vol.49 (1), p.307-314
Main Authors: Miglia, Kathleen J, Govender, Nelesh P, Rossouw, Jenny, Meiring, Susan, Mitchell, Thomas G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Biological and medical sciences
Child
Child, Preschool
Cryptococcosis - microbiology
Cryptococcus neoformans
Cryptococcus neoformans - classification
Cryptococcus neoformans - genetics
Cryptococcus neoformans - isolation & purification
DNA, Fungal - chemistry
DNA, Fungal - genetics
Female
Fundamental and applied biological sciences. Psychology
Genes, Mating Type, Fungal
Genetic Variation
Genotype
Human immunodeficiency virus
Humans
Infant
Infant, Newborn
Male
Microbiology
Miscellaneous
Molecular Sequence Data
Multilocus Sequence Typing
Mycological Typing Techniques
Mycology
Ploidies
Sequence Analysis, DNA
South Africa
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Summary:Compared to the incidence in adults, cryptococcosis is inexplicably rare among children, even in sub-Saharan Africa, which has the highest prevalence of coinfection with HIV and Cryptococcus neoformans. To explore any mycological basis for this age-related difference in the incidence of cryptococcosis, we investigated isolates of C. neoformans recovered from pediatric and adult patients during a 2-year period in South Africa. From reports to the Group for Enteric, Respiratory, and Meningeal Disease Surveillance in South Africa (GERMS-SA), we reviewed all cases of cryptococcosis in 2005 and 2006. We analyzed one isolate of C. neoformans from each of 82 pediatric patients (
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01277-10