Cystic macular oedema on spectral-domain optical coherence tomography in choroideremia patients without cystic changes on fundus examination

Purpose To determine the prevalence of cystic macular oedema (CME) in patients with choroideremia (CHM) by using spectral-domain optical coherence tomography (SD-OCT). Methods A total 16 patients affected with CHM were enroled in the study. All patients underwent a complete eye examination. SD-OCT w...

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Bibliographic Details
Published in:Eye (London) 2011-01, Vol.25 (1), p.84-90
Main Authors: Genead, M A, Fishman, G A
Format: Article
Language:English
Subjects:
631/208/2489/144
631/378/1689/1626
692/700/1421/1846
Adolescent
Adult
Biological and medical sciences
Choroideremia - complications
Clinical Study
Cohort Studies
Female
Fundus Oculi
Humans
Laboratory Medicine
Macular Edema - diagnosis
Macular Edema - epidemiology
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Miscellaneous
Ophthalmology
Pharmaceutical Sciences/Technology
Prevalence
Retina - pathology
Retinopathies
Surgery
Surgical Oncology
Tomography, Optical Coherence - methods
United States - epidemiology
Young Adult
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Summary:Purpose To determine the prevalence of cystic macular oedema (CME) in patients with choroideremia (CHM) by using spectral-domain optical coherence tomography (SD-OCT). Methods A total 16 patients affected with CHM were enroled in the study. All patients underwent a complete eye examination. SD-OCT was performed using an OPKO spectral-domain OCT/SLO instrument. Results The average age of the study patients was 44.0±16.0 years (range, 13–63 years). Out of the 16 patients with CHM, 10 patients (62.5%) showed a degree of CME on SD-OCT testing in at least one eye, and 8 patients (50%) showed CME in both eyes. Conclusions Because of its notable prevalence, it would seem prudent to screen CHM patients by SD-OCT for the possible presence of CME and to identify those amenable to future treatment strategies for their macular oedema.
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2010.157