miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis

The execution of apoptosis is critical for proper development of the nervous system. However, it is equally important that neurons strictly inhibit apoptosis after development to ensure their survival throughout the lifetime of the organism. Here we show that a microRNA, miR-29b, is markedly induced...

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Bibliographic Details
Published in:Genes & development 2011-01, Vol.25 (2), p.125-130
Main Authors: Kole, Adam J, Swahari, Vijay, Hammond, Scott M, Deshmukh, Mohanish
Format: Article
Language:English
Subjects:
Animals
Apoptosis - genetics
Apoptosis - physiology
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - metabolism
Cell Differentiation - physiology
Gene Expression Regulation, Developmental
HEK293 Cells
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
Neurogenesis - physiology
Neurons - cytology
Neurons - metabolism
Neurons - physiology
Research Communication
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Summary:The execution of apoptosis is critical for proper development of the nervous system. However, it is equally important that neurons strictly inhibit apoptosis after development to ensure their survival throughout the lifetime of the organism. Here we show that a microRNA, miR-29b, is markedly induced with neuronal maturation and functions as a novel inhibitor of neuronal apoptosis. The prosurvival function of miR-29b is mediated by targeting genes in the proapoptotic BH3-only family. Our results identify a unique strategy evolved by maturing neurons that uses a single microRNA to inhibit the multiple, redundant BH3-only proteins that are key initiators of apoptosis.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1975411