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An Embedded Subnetwork of Highly Active Neurons in the Neocortex
Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (
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| Published in: | Neuron (Cambridge, Mass.) Mass.), 2010-12, Vol.68 (6), p.1043-1050 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c522t-6b7a05382e18bfc305dc96bdf18ddbe60de7506b5d61e498292785c6c2eaa0863 |
| container_end_page | 1050 |
| container_issue | 6 |
| container_start_page | 1043 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 68 |
| creator | Yassin, Lina Benedetti, Brett L. Jouhanneau, Jean-Sébastien Wen, Jing A. Poulet, James F.A. Barth, Alison L. |
| description | Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates ( |
| doi_str_mv | 10.1016/j.neuron.2010.11.029 |
| format | article |
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− neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP
+ neurons. Paired-cell recordings indicated that fosGFP
+ neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.
[Display omitted]
► IEG expression demarcates a subpopulation of neurons with elevated firing rates ► fosGFP neurons fire more because of greater synaptic drive during network activity ► Fos-expressing neurons are highly interconnected</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2010.11.029</identifier><identifier>PMID: 21172607</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Action Potentials - physiology ; Animals ; Animals, Newborn ; Medical research ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neocortex - physiology ; Nerve Net - physiology ; Neurons ; Neurons - physiology ; Rodents ; Transgenic animals</subject><ispartof>Neuron (Cambridge, Mass.), 2010-12, Vol.68 (6), p.1043-1050</ispartof><rights>2010 Elsevier Inc.</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 22, 2010</rights><rights>2010 Elsevier Inc. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-6b7a05382e18bfc305dc96bdf18ddbe60de7506b5d61e498292785c6c2eaa0863</citedby><cites>FETCH-LOGICAL-c522t-6b7a05382e18bfc305dc96bdf18ddbe60de7506b5d61e498292785c6c2eaa0863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21172607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yassin, Lina</creatorcontrib><creatorcontrib>Benedetti, Brett L.</creatorcontrib><creatorcontrib>Jouhanneau, Jean-Sébastien</creatorcontrib><creatorcontrib>Wen, Jing A.</creatorcontrib><creatorcontrib>Poulet, James F.A.</creatorcontrib><creatorcontrib>Barth, Alison L.</creatorcontrib><title>An Embedded Subnetwork of Highly Active Neurons in the Neocortex</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity. Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here, we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP
− neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP
+ neurons. Paired-cell recordings indicated that fosGFP
+ neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.
[Display omitted]
► IEG expression demarcates a subpopulation of neurons with elevated firing rates ► fosGFP neurons fire more because of greater synaptic drive during network activity ► Fos-expressing neurons are highly interconnected</description><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Neocortex - physiology</subject><subject>Nerve Net - physiology</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Rodents</subject><subject>Transgenic animals</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EokvhHyAUiUNPWTxO_HVBrKqWVqroAThbiT3pesnaxU4W-u-bdEv5OJSTNfYz73jel5DXQJdAQbzbLAOOKYYlo_MVLCnTT8gCqJZlDVo_JQuqtCgFk9UBeZHzhlKouYbn5IABSCaoXJAPq1CcbFt0Dl3xeWwDDj9i-lbErjjzV-v-pljZwe-w-HQ3LBc-FMN6LqONacCfL8mzrukzvro_D8nX05Mvx2flxeXH8-PVRWk5Y0MpWtlQXimGoNrOVpQ7q0XrOlDOtSioQ8mpaLkTgLVWTDOpuBWWYdNQJapD8n6vez22W3QWw5Ca3lwnv23SjYmNN3-_BL82V3FnKspYxfgkcHQvkOL3EfNgtj5b7PsmYByzUVxIoaSs_08yKnUFaibf_kNu4pjC5IMBXmstuFAwUfWesinmnLB7-DVQM2dpNmafpZmzNABmynJqe_Pnxg9Nv8L7bQlOvu88JpOtx2DR-YR2MC76xyfcAulksWQ</recordid><startdate>20101222</startdate><enddate>20101222</enddate><creator>Yassin, Lina</creator><creator>Benedetti, Brett L.</creator><creator>Jouhanneau, Jean-Sébastien</creator><creator>Wen, Jing A.</creator><creator>Poulet, James F.A.</creator><creator>Barth, Alison L.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101222</creationdate><title>An Embedded Subnetwork of Highly Active Neurons in the Neocortex</title><author>Yassin, Lina ; 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Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here, we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP
− neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP
+ neurons. Paired-cell recordings indicated that fosGFP
+ neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.
[Display omitted]
► IEG expression demarcates a subpopulation of neurons with elevated firing rates ► fosGFP neurons fire more because of greater synaptic drive during network activity ► Fos-expressing neurons are highly interconnected</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21172607</pmid><doi>10.1016/j.neuron.2010.11.029</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuron (Cambridge, Mass.), 2010-12, Vol.68 (6), p.1043-1050 |
| issn | 0896-6273 1097-4199 |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Action Potentials - physiology Animals Animals, Newborn Medical research Mice Mice, Inbred C57BL Mice, Transgenic Neocortex - physiology Nerve Net - physiology Neurons Neurons - physiology Rodents Transgenic animals |
| title | An Embedded Subnetwork of Highly Active Neurons in the Neocortex |
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