Serum leptin, adiponectin and tumor necrosis factor-α in hyperlipidemic rats with/without concomitant diabetes mellitus

We compared the lipid profiles and serum levels of leptin, adiponectin and tumor necrosis factor-α (TNF-α) in rats with/without hyperlipidemia and with/without concomitant diabetes mellitus. Forty 10-wk-old male Wistar rats were divided into four groups. Groups A and C received standard food for 12...

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Bibliographic Details
Published in:Molecular medicine (Cambridge, Mass.) Mass.), 2011-01, Vol.17 (1-2), p.36-40
Main Authors: Margoni, Angeliki, Perrea, Despoina N, Vlachos, Ioannis, Prokopaki, Georgia, Pantopoulou, Alkistis, Fotis, Lambros, Kostaki, Maria, Papavassiliou, Athanasios G
Format: Article
Language:English
Subjects:
Adiponectin - blood
Animals
Biomarkers - blood
Diabetes Complications
Diabetes Mellitus - blood
Hyperlipidemias - blood
Hyperlipidemias - complications
Leptin - blood
Male
Obesity - blood
Obesity - pathology
Rats
Rats, Wistar
Tumor Necrosis Factor-alpha - blood
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Summary:We compared the lipid profiles and serum levels of leptin, adiponectin and tumor necrosis factor-α (TNF-α) in rats with/without hyperlipidemia and with/without concomitant diabetes mellitus. Forty 10-wk-old male Wistar rats were divided into four groups. Groups A and C received standard food for 12 wks. Groups B and D received a high-fat diet enriched with 2% additional cholesterol. Moreover, insulin-deficient (type I) diabetes mellitus was induced in rats in groups C and D with intraperitoneal injections of streptozotocin. Fasting serum leptin levels were decreased in diabetic groups (groups C and D) compared with controls. Fasting serum adiponectin levels were decreased in groups C and D compared with group A. Serum TNF-α levels were augmented in groups B and D, those fed with an atherogenic diet. By contrast, TNF-α levels were decreased in group C. Our data suggest that serum leptin, adiponectin and TNF-α levels may serve as markers of obesity and type I diabetes mellitus.
ISSN:1076-1551
1528-3658
DOI:10.2119/molmed.2010.00167