Systemic lupus erythematosus. Studies of the antibodies bound to skin

Systemic lupus erythematosus is characterized by antibodies demonstrable by immunofluorescence on the renal glomeruli and at the basement membrane area of both normal and involved skin. Acid eluates from glomeruli and from normal-appearing skin of three patients with systemic lupus erythematosus con...

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Bibliographic Details
Published in:The Journal of clinical investigation 1973-08, Vol.52 (8), p.1871-1880
Main Authors: Landry, M, Sams, Jr, W M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibodies - analysis
Antibodies, Anti-Idiotypic - biosynthesis
Antibodies, Antinuclear - analysis
Antibody Specificity
Antigen-Antibody Complex
Basement Membrane - immunology
Chromatography, DEAE-Cellulose
Complement Fixation Tests
Complement System Proteins - analysis
Deoxyribonucleases - metabolism
Esophagus - immunology
Female
Fluorescent Antibody Technique
Humans
Immunoglobulin G - analysis
Immunoglobulin M - analysis
In Vitro Techniques
Kidney Cortex - immunology
Kidney Glomerulus - immunology
Lupus Erythematosus, Systemic - immunology
Skin - immunology
Tissue Extracts
Trachea - immunology
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Summary:Systemic lupus erythematosus is characterized by antibodies demonstrable by immunofluorescence on the renal glomeruli and at the basement membrane area of both normal and involved skin. Acid eluates from glomeruli and from normal-appearing skin of three patients with systemic lupus erythematosus contained an antinuclear antibody. This antibody fixes complement and produces a mixed immunofluorescent pattern. Anti-deoxyribonucleic acid or antiextractable nuclear antigen antibodies may be present. This antibody is concentrated on the skin and glomerular basement membrane in proportion to the total serum IgG concentration. In two cases the skin eluate contains, in addition to the antinuclear antibody, a basement membrane antibody that fixes complement, gives a linear immunofluorescent pattern, and appears to be similar (although not identical) to the pemphigoid antibody.
ISSN:0021-9738
DOI:10.1172/JCI107370