Recurrent fever syndromes in patients after recovery from Kawasaki syndrome

The recurrence of fever in a child with a history of Kawasaki syndrome (KS) poses a dilemma for clinicians who must consider the possibility of recurrent KS. In this report we present the cases of 4 patients who presented with classical symptoms of KS, were successfully treated with intravenous immu...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2011-02, Vol.127 (2), p.e489-e493
Main Authors: Broderick, Lori, Tremoulet, Adriana H, Burns, Jane C, Bastian, John F, Hoffman, Hal M
Format: Article
Language:English
Subjects:
Analysis
Autoimmune diseases
Case Reports
Case studies
Child, Preschool
Childhood fever
Children & youth
Complications and side effects
Development and progression
Diseases
Female
Fever
Fever - diagnosis
Fever - drug therapy
Fever - etiology
Fever in children
Humans
Immune response
Immune response regulation
Immunoglobulins
Immunoglobulins, Intravenous - administration & dosage
Infant
Kawasaki disease
Kawasaki syndrome
Male
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - diagnosis
Mucocutaneous Lymph Node Syndrome - drug therapy
Pediatrics
Recovery of Function - drug effects
Recovery of Function - physiology
Recurrence
Recurrence (Disease)
Regulation
Relapse
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Description
Summary:The recurrence of fever in a child with a history of Kawasaki syndrome (KS) poses a dilemma for clinicians who must consider the possibility of recurrent KS. In this report we present the cases of 4 patients who presented with classical symptoms of KS, were successfully treated with intravenous immunoglobulin, and later experienced a reappearance of inflammatory symptoms in a pattern consistent with a recurrent fever syndrome. The association of these syndromes within the same patient suggests that some patients may have a genetic propensity toward altered immune responses and autoinflammatory syndromes. We propose that these 2 syndromes exist within a family of febrile disorders related to innate immune dysregulation.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2010-1218