Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus

Peripheral blood lymphocytes from 23 patients with active systemic lupus erythematosus (SLE) were serially studied. Changes in bone marrow-derived lymphocytes (B cells), as measured by surface Ig receptors and C3 receptors, and in thymus-derived cells (T cells) measured by rabbit T-cell-specific ant...

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Bibliographic Details
Published in:The Journal of clinical investigation 1973-12, Vol.52 (12), p.3046-3056
Main Authors: Messner, R P, Lindström, F D, Williams, Jr, R C
Format: Article
Language:English
Subjects:
Antibodies
B-Lymphocytes - immunology
Cell Membrane - immunology
Cytotoxicity Tests, Immunologic
Female
Fluorescent Antibody Technique
Humans
Immunoglobulins - analysis
Leukocyte Count
Lupus Erythematosus, Systemic - immunology
T-Lymphocytes - immunology
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Summary:Peripheral blood lymphocytes from 23 patients with active systemic lupus erythematosus (SLE) were serially studied. Changes in bone marrow-derived lymphocytes (B cells), as measured by surface Ig receptors and C3 receptors, and in thymus-derived cells (T cells) measured by rabbit T-cell-specific antiserum and E-binding techniques, were correlated with fluctuations in clinical disease activity and treatment. In normal controls B- and T-cell percentages remained relatively stable, although the situation in SLE was much more labile. A relative and absolute decrease in T lymphocytes and cells bearing a receptor for C3 was found in active lupus. Absolute numbers of cells bearing surface Ig were decreased to a lesser extent, whereas the proportion of these cells was increased. It is postulated that the increase in autoantibody formation and diminished delayed hypersensitivity seen in systemic lupus may be due to a loss of T-lymphocyte function.
ISSN:0021-9738
DOI:10.1172/jci107503